Home / NewTech / Scientists reverse Parkinson’s disease in mice by optimizing the genetic code of non-neuronal brain cells – Technology News, Firstpost

Scientists reverse Parkinson’s disease in mice by optimizing the genetic code of non-neuronal brain cells – Technology News, Firstpost



Scientists are developing a unique treatment that seems to permanently cure Parkinson’s disease in mice.

The results of the study, which was carried out by researchers from the University of California, have been published in science diary nature.

According to the authors of the study, they hope that the same approach can be used to treat a variety of human neurodegenerative diseases.

After a Report in IFL science, Parkinson̵

7;s and other types of dementia occur when neurons are damaged and die. For decades, scientists have tried to develop treatments to protect brain cells or to generate new ones to replace the lost ones.

The authors of the study could now do this by modifying a single gene.

The report mentions that researchers have optimized the genetic code of non-neuronal brain cells called astrocytes in petri dishes. The astrocytes facilitate communication throughout the brain by producing a protein called PTB, which ensures that they don’t turn into neurons.

When researchers blocked PTB’s production, the astrocytes turned into neurons.

    Scientists reverse Parkinson's disease in mice by optimizing the genetic code of non-neuronal brain cells

Left: mouse astrocytes (green) before reprogramming; Right: Neurons (red) induced from mouse astrocytes after reprogramming with PTB antisense oligonucleotide treatment. Photo credit: University of California

After a University of California statement releasedLead author Xiang-Dong Fu said, “Researchers around the world have tried many ways to create neurons in the laboratory using stem cells and other means so that we can better study them and replace lost neurons in neurodegenerative diseases,” added: “The fact it was a big surprise that we were able to produce so many neurons in such a relatively simple way. “

After a Report in EurekalertThe researchers developed a non-infectious virus that carries an antisense oligonucleotide sequence and administered it directly to the mouse midbrain, which is responsible for regulating motor activity and reward behavior, as well as the part of the brain that produces dopamine-producing neurons in Parkinson’s disease loses. A control group of mice received sham treatment.

According to the report, a small subset of astrocytes converted to neurons in the mice that were treated properly, increasing the number of neurons by approximately 30 percent. The researchers also found that dopamine levels were restored to a level comparable to that in normal mice. They found that the neurons grew and sent their processes to other parts of the brain, and the mice returned to normal within three months after a single treatment.

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